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Tell individuals that: Tramadol Hydrochloride Prolonged-Release is for oral use only and may be swallowed entire. The capsule shouldn't be chewed, dissolved, crushed or split. Tramadol Hydrochloride Prolonged-Release might bring about seizures and/or serotonin syndrome with concomitant use of serotonergic brokers (like SRIs, NRIs, and triptans) or